Guide PCP Dependence: Facts and Treatment Options

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Medical personnel can also deal with complications, such as rhabdomyolysis, which is a condition that occurs when muscle tissue begins to break down and proteins are released in the blood. This condition can be very serious and may have potentially fatal consequences. Some individuals may continue to display psychotic behaviors for a significant length of time following an overdose of PCP.

These individuals may need long-term treatment for this behavior. Individuals who continue to display psychotic behaviors after a PCP overdose and had no prior history of psychosis may have damaged certain areas of the brain that are involved in perception and reasoning.

PCP Statistics

Other organs, such as the heart, liver, and kidneys, can also suffer irreversible damage as a result of reduced blood flow and oxygen. Follow-up care typically includes referring the individual for substance use disorder treatment, continued outpatient therapy, the use of benzodiazepines to avoid seizures, and the continued use of antipsychotic medications as needed.

Because an individual who has overdosed on PCP is at extreme risk for even more severe and potentially permanent effects if they continue to use the drug, it is extremely important that every effort be made to involve them in a formal substance use disorder treatment program. This includes helping the individual avoid use of other drugs of abuse as the damage that may have occurred as a result of a PCP overdose may leave them very vulnerable to future damage from other substances.

Verify Benefits. Home PCP abuse how to treat overdose. Last Updated: June 10, It is hypothesized that: PCP has an inhibitory effect on the neurotransmitter NDMA N-methyl-D-aspartate , an important excitatory neurotransmitter that is involved in many different functions, including learning and memory, perception, and attention. PCP affects the D2 dopamine receptor, which is a receptor that is also implicated in psychotic behaviors, such as in individuals with schizophrenia.

Its actions on dopamine may explain some of its hallucinogenic effects. PCP inhibits the effects of the neurotransmitter acetylcholine, which is involved in movement and memory.

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PCP has an effect on certain serotonin receptors. PCP facilitates the actions of endorphins and enkephalins, which are involved in diminishing the experience of stress, exertion, and pain. PCP was originally designed to be an anesthetic, and these actions may explain some of its anesthetic effects.

There are no specific drugs that can be used to treat a PCP overdose. Pain relief. Distorted sensory perception. Feelings of invulnerability and strength. Feelings of detachment. Excessive anxiety. Psychotic symptoms, including paranoia. Concentration problems. Amnesia or memory loss. Bizarre behaviors. Increased heart rate and blood pressure.


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Rise in body temperature. Excessive sweating. Blurred vision. Speech problems. Loss of body control. Memory loss.


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  • Speech and cognition problems. Weight loss. Abnormal liver function. Rhabdomyolysis the breakdown of muscle tissue, which can lead to kidney failure. Social withdrawal or isolation. Suicidal thoughts. Interpersonal or social problems. Financial hardships. Chronic absenteeism from school or work. Job loss. Child neglect. Loss of custody. Exacerbation of physical and mental health problems. A larger amount of PCP is used than previously intended. The user experiences failed attempts to cut back or quit using PCP.

    Excessive time is spent getting PCP, using it, and recovering from side effects. The user has strong urges to use PCP. PCP is abused despite school, work, or home consequences. PCP is used in spite of social or interpersonal issues worsened or caused by the substance. PCP is abused in favor of important social, occupational, or recreational activities. Use of PCP in perilous situations, such as while driving a car.

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    PCP is used in spite of physical and psychological problems exacerbated or caused by the drug. The user needs more PCP to achieve the desired results, or the same dose produces a diminished effect.


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